- Debut: The Amazing Spider-Man #6 (November 1963)
- Created By: Stan Lee & Steve Ditko
The story revolving around this character has altered a bit over the years. However, the original is the one people know best. Dr. Curt Connors worked as a surgeon for the U.S. Army, where he performed emergency battlefield surgeries. Yet during one wartime blast, his arm was badly injured and had to be amputated. When he returned home, Connors became a notable geneticist. Obsessed with reptiles and how lizards especially grew back limbs like tails, he developed a serum based on lizard DNA. Ideally, if it works, humans will be able to grow back missing limbs too. Confident in his research, he tests this on himself.
While his arm did come back, the serum changed him into a human-sized lizard. While Spider-Man helped to undo the transformation, The Lizard remained a part of Connors’ mind. Thus, he’d come back off and on. Eventually, The Lizard was able to retain all of Connor’s intelligence, accompanied by a warped mind. In fact, he tried to turn mankind into reptiles just like him a few times. Dr. Connors often suffers from the Lizard’s effect on his mind, making him live in constant fear that it’ll return one day and take him over for good. While The Lizard might be one of the most notable Spider-Man villains, Connors is a dear friend that Spidey often tries to help.