Malaria is often not a problem in the developed world. In fact, most developed nations rarely even see insects that carry malaria at all. But in places like Africa and parts of Asia, malaria is a huge problem. Yet the problem could reduce sooner rather than later thanks to human evolution. Back in the 1940s and 1950s, scientists J.B.S. Haldane and A.C. Allison found a sickle-cell mutation known as Glu6Val in the beta hemoglobin gene known as HBB. This mutation proved to be resistant to malaria.
More mutations have occurred in the HBB area as well. On top of this, the Duffy antigen gene or FY has also mutated for some people. FY is a membrane protein used by the Plasmodium Vivax malaria parasite to access human red blood cells. Mutation to this FY system stopped malaria right at the access point, preventing it from starting at all. In fact, this specific trait has now been seen in 100% of cases for people in Sub-Saharan Africa, but nowhere else as of yet.