Colgan Air Flight 3407 (2009)
It comes as no surprise that pilots suffer fatigue mid-flight. That’s exactly what happened to this Bombardier Dash 8-Q400, which forced changes in pilot training and fatigue regulations. During the flight, “The captain responded to the device improperly, and the stick pusher activated to prevent the aircraft from stalling. The captain overpowered the stick pusher. Furthermore, the first officer lowered the flaps, which was a mistake. The aircraft stalled and crashed into a house in Clarence Centre in the state of New York.” All the passengers and crew perished, forcing aviation to rethink how they train pilots (Aerotime).