2. Transparent Frogs
Scientists have applied advanced chemical clearing techniques—originally optimized for mouse organs—to juvenile frogs, rendering their skin nearly transparent. The process, known as CUBIC (Clear, Unobstructed Brain/Body Imaging Cocktails), dissolves lipids and pigments without damaging proteins. Nature Protocols
By scanning living frogs under fluorescent microscopes, researchers can observe heartbeats, organ development, and neural activity in real time. This non-invasive method accelerates research on amphibian physiology and disease, eliminating the need for traditional dissection and preserving specimens for longitudinal studies.