Turkish Airlines Flight 981 (1974)
During an unfortunate flight in 1974, a Turkish Airlines flight experienced a DC-10 cargo door failure. This led to design changes and safety improvements to prevent it from ever happening again. All 346 people were killed in the crash. Only nine minutes into the flight, the cargo door on the lefthand side burst open. This caused a violent decompression in the aircraft, and two rows of three passengers were immediately evicted from the airplane. This then caused an immediate descent of the aircraft until it crashed into the ground. This fault in design prompted engineers to improve their safety requirements (Aerotime).