ValuJet Flight 592 (1996)
Because of this fatal crash, it prompted changes in hazardous materials handling. After this crash, the airline mechanic went on the run to hide from charges that would inevitably send him to jail. Pilots lost control of the airplane only a few minutes into the flight when a fire started in the cockpit and sent the plane on fire. It’s speculated that one tire in the freight of the belly exploded during takeoff, contributing to the fire (Click Orlando).