Mister Sinister
- First Appearance: The Uncanny X-Men Vol. 1 #221 (1987)
- Created By: Chris Claremont & Peter Milligan
Mister Sinister ranks as one of the greatest villains in comic book history. Yet his creation actually came out of frustration with the X-Men constantly having to go up against Magneto and the Brotherhood for writer Chris Claremont. Sinister gave them a chance to explore new storylines, especially those that could get incredibly personal. However, Sinister himself rarely found himself involved in conflicts as he thought of himself s “just a scientist.” Often, he uses assassins and other agents to do his fighting for him. However, he is like an evil Charles Darwin. He’s obsessed with engineering the perfect superhuman.
An encounter with Apocalypse leads to the once known “Nathaniel Essex” becoming Mr. Sinister. This made Essex ageless and regenerative, which allows him to continue his obsession, now with minor powers he could get through experimentation. Sinister would become obsessed with Cyclops and Jean Grey, believing them to be the perfect beings. Thus, he constantly tries to get their DNA somehow. It even becomes such an issue, the two have to travel to the future to be safe at one point. Sinister is rumored to be the villain for Deadpool 3 or Avengers 5 and could serve a larger role in storylines going forward.