Unintentional weight gain can be both frustrating and confusing, especially when you’re already making healthy lifestyle choices. Sometimes, the culprit may not be your diet or lack of exercise, but rather something hidden in your medicine cabinet. Many widely used prescription and over-the-counter medications list weight gain as a potential side effect, whether through increased appetite, a slower metabolism, or water retention. Recognizing these connections is the first step toward regaining control over your weight. In this article, we’ll explore 25 common medications that could be influencing your body weight—and what you can do about it.