The search for life beyond Earth is one of humanity’s most profound scientific quests. Scientists scour the cosmos not only for direct evidence, but also for subtle, indirect signs that might hint at alien existence. Since we haven’t yet encountered extraterrestrials face-to-face, researchers rely on a growing toolkit of observational techniques and analytical methods. They monitor the skies for chemical signatures, unusual signals, and even planetary behaviors that could suggest life. Every new discovery brings us closer to answering the age-old question: Are we alone in the universe?