16. Disorders Linked to DMN Dysfunction

Dysfunction in the default mode network has been linked to several neurological and psychiatric conditions. Research shows that abnormal DMN activity is associated with depression, Alzheimer’s disease, and ADHD. For example, excessive rumination in depression may stem from an overactive DMN, while disruptions in connectivity are seen in Alzheimer’s patients. These findings highlight the DMN’s essential role in healthy brain function and underscore why its balance is crucial for mental and cognitive well-being.