6. The Role of Galactose-α-1,3-Galactose

At the core of alpha-gal syndrome is the sugar molecule galactose-α-1,3-galactose, commonly called alpha-gal. This molecule is naturally present in the tissues of most non-primate mammals, like cows, pigs, and sheep. When a tick bite introduces alpha-gal into the bloodstream, the immune system of some people targets it as a foreign invader, setting the stage for potentially severe allergic reactions after consuming red meat.