Colossal Only Modified 20 Changes to 14 Genes

Expert commentary in Scientific American underscores just how limited Colossal’s genetic edits were—only 20 targeted changes affecting 14 genes. In the context of millions of genetic differences, this is a minuscule intervention. Scientists argue that such a narrow scope can’t begin to recreate the full complexity of an extinct species, highlighting the vast gap between genetic engineering and true de-extinction.