Challenges and Limitations
Despite their promise, DNA nanobots face several significant challenges. Maintaining stability in the complex environment of the human body is difficult, as natural enzymes can degrade DNA structures. Potential immune responses and the complexities of large-scale, reproducible manufacturing also present hurdles. Ongoing research, such as work highlighted in this Nature Nanotechnology article, is focused on enhancing durability, improving delivery methods, and scaling up production to bring these breakthroughs closer to widespread clinical use.