Marfan Syndrome

• Percentage Of People Who Have It: Just Under 20%

Marfan Syndrome can be hard to deal with but it does offer incredible flexibility. This is one of those rare genetic traits that most parents do not want to pass on to their children. The syndrome affects a person’s body tissue where they will be tall and lanky but also have elongated limbs. While being tall and lanky is not so much an issue, the trouble with something like this is what happens on the inside of the body. A person’s heart, eyes, blood vessels, and overall skeleton can be impacted.

For many, their bones will dislocate easily without any major stress to force them to do so. The syndrome also causes extra strain on a person’s aorta and will usually always cause early-onset arthritis. There are some who have a less impactful version of the condition where their ligaments grow long and stretchy to offer hypermobility, but they are otherwise healthy. It is actually a bit more common than some might assume, as 1 in 5,000 people are born with the genetic mutation today.

Deficiency In PCSK9

• Percentage Of People Who Have It: Around 2%

While ever wishing to have a major deficiency in normal parts of the body would be a bad thing, it might not be in some specific situations. When it comes to rare genetic traits, one might love to have a deficiency in their Proprotein Convertase Subtilisin/Kexin Type 9 gene. Otherwise known as the PCSK9 gene, some people are born with a much smaller amount of this gene than the rest of us.

Having this deficiency can be a blessing in disguise, as it allows a person to have a reduced risk of heart disease by up to as much as 90 percent! On top of this, they do not have to worry about their cholesterol numbers like others. However, this deficiency does come with some drawbacks. The deficiency allows one to have an increased number of cholesterol esters, but this will impact glucose-stimulated insulin secretion. That will cause hyperglycemia and even impaired glucose tolerance.

Unbreakable Bones

• Percentage Of People Who Have It: Less Than 5%

When we state “unbreakable bones,” we want to make sure to reference that it is possible for anyone to break a bone. Yet there is a condition that simply makes it nearly impossible for certain people to do so. While it might not be one of the most well-known rare genetic traits, it is starting to rise in popularity. Called the LRP5 mutation, those affected by this will regulate and produce proteins that lead to a rise in bone density. The genetic mutation was relatively unknown until a car crash happened in 1994.

A man was involved in what was said to be an incredibly serious car accident but he did not break or even fracture a single bone. Researchers looked into this person further and eventually found that he had family members who also had strong skeletons. One family member actually underwent several failed hip replacements because surgeons could not screw into their bone. Further testing of the family members found that their bones were eight times as dense as the average person’s. This made their bones nearly impossible to break, at least under a normal situation.

Albinism

• Percentage Of People Who Have It: Around 6%

While some might say this is a questionable addition to our list of rare genetic traits, it actually counts a lot. Those with albinism are able to pass on this exact condition to their offspring. Of course, this is not always the case and a person can avoid albinism completely. It is obviously a lot easier to get if a person has two albino parents versus one. There are also two forms of albinism, Oculocutaneous (OCA) and Ocular Albinism (OA). Both have an effect on hair, skin, and eye pigmentation.

OCA mostly affects skin pigmentation but OA mostly affects a person’s eyes. But both could have normal looks for hair, eyes, or skin depending on the one you get. The National Organization for Albinism and Hypopigmentation claims skin and hair for people with OA might appear similar or only slightly lighter than other family members. Albinism overall is rare but OA is the rarest form of the condition, and can also cause several eye-related problems. Roughly 1 in 20,000 are albino today.

Left-Handedness

• Percentage Of People Who Have It: 15%

Some people claim that left-handedness has nothing to do with genetics, but this is highly untrue. If you have a left-handed parent, there is a solid chance you or a sibling will be left-handed. If you have two parents that are lefties, it is almost certainly their offspring(s) will be too. Although this has been studied for hundreds of years, we are just now coming to the conclusion that there is a biological, genetic cause for people being left-handed.

Some felt that hand preference was caused psychologically by the parent, but this was proven to be untrue. We now know two alleles are the cause of hand preference. Scientists found that the D-Gene and C-Gene, the two alleles, were responsible for everything. Those born with the D-Gene end up right-handed a majority of the time. Those born with the C-Gene, far less common, will have a random hand preference. This allows them to literally pick their left in a 50/50 split.

Ambras Syndrome

• Percentage Of People Who Have It: Less Than 1%

Ambras Syndrome is often referred to as the “werewolf disease.” The more scientific name for this is hypertrichosis, however. Those who have it will be completely covered in hair all over their bodies, regardless of gender/sex. For some, it might be isolated to certain areas of the body but most will be covered entirely. Those who have Ambras will not just be covered in a little hair. Rather, it is usually long, thick hair that can make one resemble our ancestors, the great ape. It rose to notoriety during the Middle Ages, mostly in Europe. Only 50 people were said to have had it since then.

However, a relatively large family was eventually uncovered that had been living away from civilization for decades in an attempt to avoid issues with the public. It is now estimated several more could exist but might be hiding out. The gene responsible for this condition is called “TRPS1.” This gene causes a disruption in messages sent to cells regarding the development of follicles, which then results in the excessive hair growth Ambras Syndrome causes. Treatment now exists for people affected. This is almost always genetic, but there are some medical conditions or medicines that cause it too.

Superhuman Taste Buds

• Percentage Of People Who Have It: Roughly 25%

Rare genetic traits like superhuman taste buds might seem odd. However, those with this ability are able to accurately taste pretty much anything added to what they consume. How are they able to become superheroes in the culinary field? They are born with more visible taste papillae. These are those tiny dots everyone has on their tongue. Everyone has some visible versions of these dots, but these people have them in abundance.

This is useful but also problematic. Those with this tasting ability are more sensitive to foods, meaning that won’t be able to handle something that is very bitter, sweet, or salty. On top of this, they have more pain receptors on their tongue which makes them dislike spicy foods. Many who have superhuman taste buds do not like vegetables due to their bitter taste but they are not usually out of shape. This is due to the fact that they also do not like to consume a lot of sweet or fatty foods.

Tetrachromacy

• Percentage Of People Who Have It: Less Than 15%

Likely one of the most useful rare genetic traits anyone could have is tetrachromacy. It is possible that many of the world’s greatest artists had some form of it. This genetic trait affects how a person sees our broad color spectrum. Normal people are born with three cones in our eye to see the spectrum but some are born with a rare fourth cone. This might not seem like a lot, but that extra cone allows them to see and specifically find the difference in up to 100 million colors.

People with three cones, normies, can only see up to 1 million colors. That is a massive difference. This trait can be seen in men, but more often affects women. In fact, it is estimated up to 12% of the world’s female population are tetrachromats. It makes you wonder… if many women are born with this fourth cone, why do we not hear about it more? Apparently, a rogue X chromosome inactivation can shut off the visibility of this fourth cone in some women.

Heart On Opposite Side Of Chest

• Percentage Of People Who Have It: Less Than 1%

It would be irresponsible of us to not first mention some important anatomy information. The heart is NOT on the left side of our chest. Rather, it’s in the middle of our chest. However, it does partially go into the left side with the valves and other critical sections of the heart. Therefore, this is why people tend to believe it is completely located on the left. Just remember the bulk of the heart is mostly in the center. However, some are born with their heart leaning to the right side instead.

This is a genetic trait that is referred to as dextrocardia. Since it is mostly the valves and other portions of the heart leaning to the right, there are no real negative consequences from it. The main heart is still in the middle, of course. Therefore, do not assume someone is from another universe due to their heart being toward the right rather than the left. It is speculated that this has happened for thousands of years, and no one was ever better or worse off from it.

High Altitude Tolerance

• Percentage Of People Who Have It: Less Than 5%

If you are wanting to climb Mount Everest, you’re likely going to have a guide. This will almost always be a member of the Sherpas. They have lived around these Tibetan mountains for generations. They know the mountains well, especially Everest, which is why they guide so many. This is the most dangerous job in the world, but the pay is massive for the Tibetan and Nepalese people. Due to being here for generations, these people have developed a rare genetic trait. They can breathe normally at high altitudes, which normally makes even the most experienced non-native climbers sick.

The gene these native people possess goes back 40,000 years. People known as the Denisovans lived in these mountainous regions, and the generations that followed began to develop their incredible genetics. This supergene they have causes an increase in the oxygen-carrying hemoglobin, allowing the body to distribute oxygen more effectively. People with this gene can perform major manual labor tasks in high altitudes without experiencing oxygen deprivation. They can also breathe well in lower altitudes and still keep their incredible ability when they go back into higher altitudes.

Blue Eye Color

• Percentage Of People Who Have It: Around 8%

Blue eye color is not normal in the slightest and anyone who has this color has a mutation in their genetics. This might sound weird or scary, but it’s not that big of a deal. It began thousands of years ago when people began moving out of civilizations in the Middle East and into colder European sectors. Melanin began to change for these people as they no longer operated as often outdoors due to the far colder temperature. Eventually, the white caucasian skin color came from this.

Yet melanin did not stop with skin color, it also affected hair color and eventually the eyes. When it comes to blue eyes specifically, a genetic mutation in the HERC2 gene is to blame. This mutation causes reduced melanin production in the iris, which can offer a beautiful blue color. However, the lack of melanin also means those with blue eyes will be more sensitive to light. For example, they might need sunglasses in even small sunlight or have trouble driving at night due to lights on the road.

Golden Blood

• Percentage Of People Who Have It: Less Than 0.5% (Only 43 People Have Ever Reported To Have It)

We should state that we do not literally mean blood made of gold or gold-colored blood. Rather, this name typically comes from the rarity of this blood type. It is so rare that most hospitals have only a small supply of it or none at all. The “golden blood” is officially called the RH Null blood type. Basically, those with this blood type are missing all of their RH-blood antigens. Interestingly, anyone with another rare RH blood type can accept this blood type from donors.

As you can assume, since RH blood types are rare themselves, having RH Null blood around to give to ANY within the RH group is massively valuable. That is why those with this blood type are asked to donate as much blood as they can, as the medical community needs it in hospitals. However, due to the need hospitals have for it, RH Null blood is heavily needed for those who study blood too. If RH Null people did not exist, it could take literally months to years to find a specific RH donor.

SOURCES:

National Institutes Of Health

National Academy Of Sciences For The United States Of America

The New England Journal Of Medicine

American Academy of Ophthalmology

Centers For Disease Control & Prevention (CDC)

Mayo Clinic

University of California – San Francisco

BBC

Scientific American

Physiopedia

Live Science

Nature.com