8. Soluble TREM2 (sTREM2)
Soluble TREM2 (sTREM2) serves as a biomarker for microglial activation, reflecting the brain’s innate immune response. Elevated sTREM2 levels in cerebrospinal fluid have been linked to early progression of Alzheimer’s disease. As highlighted in Science Translational Medicine, monitoring sTREM2 may help track disease activity and support early intervention strategies.