Neurons from rat brain tissue stained green with antibody to ubiquitin C-terminal hydrolase L1 (UCH-L1) which highlights the cell body strongly and the cell processes more weakly. Astrocytes are stained in red with antibody to the GFAP protein found in cytoplasmic filaments. Nuclei of all cell types are stained blue with a DNA binding dye. Antibodies, cell preparation and image generated by EnCor Biotechnology Inc. Source: Wikipedia
Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) plays a crucial role in the breakdown and recycling of proteins in neurons.
Elevated UCH-L1 levels in cerebrospinal fluid are associated with early neurodegeneration, making it a useful complementary marker alongside others.
For an in-depth analysis, refer to Biomarkers in Medicine.
